PIA Executive Committee:
Design and Data Analytics
Chair: Graciela Muniz Terrera, PhD
Dr. Muniz Terrera is a Senior Lecturer in Biostatistics and Epidemiology at the Centre for Dementia Prevention where she works in collaboration with colleagues in the EPAD (European Prevention of Alzheimer's Dementia) and the IALSA (Integrative Analysis of Longitudinal Studies of Ageing) network of longitudinal studies of ageing and dementia.
Graciela completed her PhD at the University of Cambridge, MRC Biostatistics Unit. Following her PhD she worked in Cambridge for several years before moving to University College London where she was a Lecturer and Programme Leader Track at the MRC Lifelong Health and Ageing Unit. Her research has been supported by various funding bodies, including the MRC Career Development Award in Biostatistics, the Alzheimer's Society and the IALSA Programme Grant from the US National Institute of Health.
She has extensive experience developing and applying longitudinal methods to gain a better understanding of ageing and dementia. She is also interested in harmonisation methods for evidence synthesis and reproducible research.
Vice Chair: Michael Donohue, PhD
Dr. Donohue co-leads the Alzheimer's Clinical Trial Consortium (https://www.actcinfo.org/) biostatistics unit and is Associate Director of the Alzheimer's Therapeutic Research Institute (https://keck.usc.edu/atri/) at the University of Southern California. He has worked as a study biostatistician for Alzheimer’s observational studies and clinical trials since 2005, including the Alzheimer's Disease Neuroimaging Initiative (ADNI). Dr. Donohue's lab develops and applies novel statistical models to help design, simulate, and execute efficient clinical trials that are robust to missing data. He helped design the first intervention in asymptomatic AD, the Anti-Amyloid Treatment for Asymptomatic AD (A4; in collaboration with Eli Lilly), and its primary outcome measure, the Preclinical Alzheimer Cognitive Composite (PACC). Dr. Donohue’s methodological interests include novel models of the long-term trajectories of key markers of Alzheimer's (from pre-symptomatic to late-stage dementia), including multivariate outcome models, latent-time models, and Bayesian hierarchical models.
Programs Chair: Ana Capuano, MPS, MS, PhD
Dr. Capuano is associate professor of neurological sciences and faculty statistician of the Rush Alzheimer’s Disease Center. Capuano received her PhD from the University of Iowa. She has made wide-ranging contributions to statistical methods that are applied to modeling cognitive decline, depression scales and other outcomes of Alzheimer's research. For over 14 years, she works as a biostatistician in collaboration with psychologists, infection diseases scientists, neurosurgeons, neurologists, neuroscientists and other researchers in the development and application of modern statistical methods in epidemiological studies and clinical trials. She authored over 68 original peer-reviewed publications, cited in 3,356 times by Nov/2019. She also has book chapters in the area of statistics and study design. Capuano’s methodological interests include non-linear mixed model, as well as constrained ordinal class of models and extensions.
She has taught several courses in statistics and currently serves as director in several educational initiatives such as the Rush Alzheimer's Disease Center Neuroepidemiology Seminar and the Rush University Medical Center Biostatistics Intramural Group Discussions and Peer-to-Peer Education. She also serves in advisory boards and as reviewer of grants and scientific papers.
Member at Large: Sharon Xie, PhD
Dr. Sharon Xie is a Professor of Biostatistics in the Department of Biostatistics, Epidemiology and Informatics at the Hospital of the University of Pennsylvania, and Director of the Biostatistics Core of Penn’s Alzheimer’s DIsease Core Center (ADCC).
Immediate Past Chair: Scott Hofer, PhD
Scott Hofer is Director of the Institute on Aging and Lifelong Health, Professor of Psychology, and holds the Harald Mohr, M.D. and Wilhelma Mohr, M.D. Research Chair in Adult Development and Aging at the University of Victoria. He is Past President of Division 5 (Quantitative and Qualitative Methods) of the American Psychological Association, Past President of the Society of Multivariate Experimental Psychology, and a Fellow of the Academy of Behavioral Medicine Research, American Psychological Association, Canadian Academy of Health Sciences, Gerontological Society of America, and the Royal Statistical Society. In 2016, he received an honorary doctorate from the University of Gothenburg. He currently serves on the Council of Representatives, Federation of Associations in Behavioral and Brain Sciences.