PIA Executive Committee:



Sleep and Circadian Rhythms

 


Chair: Géraldine Rauchs

I work at the French National Institute of health and Medical Research (Inserm). My work aims at better understanding the associations between sleep quality, assessed using different tools, and structural, functional and molecular brain alterations in aging and in the early stages of Azheimer’s disease. I am also interested in the role of sleep in memory consolidation. I use various methodologies such as polysomnography, spectral analyses, neuroimaging (structural and functional MRI, PET), actigraphy and cognitive testing. 

I am also member of the scientific committee of the French Society for Sleep Research and Medicine (SFRSMS).
Relevant publications:

André C, Rehel S, …, Chételat G, Rauchs G; for the Medit-Ageing Research Group. Association of sleep-disordered breathing with Alzheimer's disease biomarkers in community-dwelling older adults: A secondary analysis of a randomized clinical trial. JAMA Neurol., 2020 Mar 23. doi: 10.1001/jamaneurol.2020.0311. André C, Tomadesso C, de Flores R, Branger P, Rehel S, Mézenge F, Landeau B, Sayette V, Eustache F, Chételat G, Rauchs G. Brain and cognitive correlates of sleep fragmentation in elderly subjects with and without cognitive deficits. Alzheimers Dement (Amst)., 2019, 11:142-150.  

Branger P, Arenaza-Urquijo EM, Tomadesso C, Mézenge F, André C, de Flores R, Mutlu J, de La Sayette V, Eustache F, Chételat G, Rauchs G. Relationships between sleep quality and brain volume, metabolism and amyloid deposition in late adulthood. Neurobiol. Aging, 2016, 41: 107-114.   



Vice Chair: Sharon Naismith
Prof Naismith is a Clinical Neuropsychologist, National Health and Medical Research Council (NHMRC) Dementia Leadership Fellow and the Leonard P Ullman Chair in Psychology at the University of Sydney, Australia. 
She leads as Chief Investigator an NHMRC Centre of Research Excellence to “Optimise Sleep in Brain Ageing and Neurodegeneration (CogSleep)”. She is also a Chief Investigator on the NHMRC Australian Dementia Network (ADNeT), and leads the nationwide memory clinics initiative. She is Chair of the Sydney Dementia Network and in 2019, formed the Global Consortia for Sleep, Ageing and Neurodegeneration.  She has expertise in modifiable risk factors for dementia including depression, cardiovascularcognitive training and sleep and circadian disturbance and has published over 275 articles. She is interested in the neuroimaging correlates of sleep disturbance in older people, screening for sleep disturbance in ‘at risk’, older adults, delineating how changes in sleep contribute to poor learning and memory in MCI, and in interventions targeting sleep disturbance. She leads a multidisciplinary team of over 20 ECRs, clinician scientists and students.  


Programs Chair: Erik Musiek
I am an Associate Professor of Neurology at Washington University School of Medicine in St. Louis, MO, USA. My research focuses on how the circadian clock in the brain of mice regulates glial activation, oxidative stress, synaptic degeneration, and pathogenic protein aggregation in models of Alzheimer’s Disease (AD). My lab and collaborators also study how circadian dysfunction contributes to AD pathogenesis in humans, with an aim to  develop new biomarkers of AD based on circadian transcriptomics.I am also a practicing neurologist with a specialization in dementia and conduct human AD research at the Knight AD Research Center at Washington University. I am a member of the Sleep Research Society Scientific Content Committee, site PI for the Longitudinal Early-onset Alzheimer’s Disease Study (LEADS), and a standing member of the NIH Neuroimmunology, Neuroendocrinology, Rhythms, and Sleep (NNRS) study section

Select Publications:
Musiek ES, Lim MM, Yang G, Bauer AQ, Qi, L, Lee, Y, Roh, JH, Ortiz-Gonzalez X, Dearborn JT, Culver JP, Herzog ED, Hogenesch JB, Wozniak DF, Dikranian K, Giasson BI, Weaver DR, Holtzman DM, FitzGerald GA (2013) Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J Clin Invest, 123; 5389-400.

Musiek ES and Holtzman DM (2016) Mechanisms linking circadian clocks, sleep, and neurodegeneration. Science, 354: 1004-8.

Musiek ES, Bhimasani M, Zangrilli MA, Morris JC, Holtzman DM, Ju YS (2018) Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease. JAMA Neurol, 75:582-590

Kress GJ, Liao F, Dimitry J, Cedeno MR, FitzGerald GA, Holtzman DM, Musiek ES (2018) Regulation of amyloid-β dynamics and pathology by the circadian clock. J Exp Med, 215:1059-1068.

Lananna BV, Nadarajah CJ, Izumo M, Cedeño MR, Xiong DD, Dimitry J, Tso CF, McKee CA, Griffin P, Sheehan PW, Haspel JA, Barres BA, Liddelow SA, Takahashi JS, Karatsoreos IN, Musiek ES (2018) Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1. Cell Rep, 25:1-9.e5

 Communications Chair: Julie Carrier
I am Professor in Psychology at the Université de Montréal and Fellow of the Canadian Academy of Health Science.  I am the scientific director of the Canadian Sleep and Circadian Network (https://www.cscnweb.ca/) and the Canadian Public Health Campaign “Sleep on it” (https://sleeponitcanada.ca/).   I am co-leading, with Andrew Lim (University of Toronto), the Sleep and Dementia team of the Canadian Consortium on Neurodegeneration in Aging.  I published more than 165 peer-reviewed scientific articles.  My work identified key mechanisms underlying age-related changes in the sleep-wake cycle and their functional consequences on physical and cognitive health in normal and pathological aging. In collaboration with several international groups, my research team contributed to the development of several methodological tools in sleep and circadian research (e.g. combined EEG-fMRI and EEG-MEG sleep studies, evaluation of light sensitivity using fMRI). 
Selected publications
Bouchard M, Lina JM, Gaudreault PO, Dubé J, Gosselin N, Carrier J. EEG connectivity across sleep cycles and age. Sleep. 2020 Mar 12;43(3):zsz236. doi: 10.1093/sleep/zsz236. 

Latreille V, Gaubert M, Dubé J, Lina JM, Gagnon JF, Carrier J. Age-related cortical signatures of human sleep electroencephalography. Neurobiol Aging. 2019 Apr;76:106-114. doi: 10.1016/j.neurobiolaging.2018.12.012. 

Daneault V, Dumont M, Massé É, Forcier P, Boré A, Lina JM, Doyon J, Vandewalle G, Carrier J. Plasticity in the Sensitivity to Light in Aging: Decreased Non-visual Impact of Light on Cognitive Brain Activity in Older Individuals but No Impact of Lens Replacement. Front Physiol. 2018 Nov 6;9:1557. doi: 10.3389/fphys.2018.01557. 

Baril AA, Carrier J, Lafrenière A, Warby S, Poirier J, Osorio RS, Ayas N, Dubé MP, Petit D, Gosselin N; Canadian Sleep and Circadian Network. Biomarkers of dementia in obstructive sleep apnea. Sleep Med Rev. 2018 Dec;42:139-148. doi: 10.1016/j.smrv.2018.08.001.

Gaudreault PO, Gosselin N, Lafortune M, Deslauriers-Gauthier S, Martin N, Bouchard M, Dubé J, Lina JM, Doyon J, Carrier J. The association between white matter and sleep spindles differs in young and older individuals. Sleep. 2018 Sep 1;41(9):zsy113. doi: 10.1093/sleep/zsy113.  

Latreille V, Carrier J, Gaudet-Fex B, Rodrigues-Brazète J, Panisset M, Chouinard S, Postuma RB, Gagnon JF. Electroencephalographic prodromal markers of dementia across conscious states in Parkinson's disease. Brain. 2016 Apr;139(Pt 4):1189-99. doi: 10.1093/brain/aww018. 

CURRENT ISTAART PIAS 

  Cognition

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