She leads as Chief Investigator an NHMRC Centre of Research Excellence to “Optimise Sleep in Brain Ageing and Neurodegeneration (CogSleep)”. She is also a Chief Investigator on the NHMRC Australian Dementia Network (ADNeT), and leads the nationwide memory clinics initiative. She is Chair of the Sydney Dementia Network and in 2019, formed the Global Consortia for Sleep, Ageing and Neurodegeneration. She has expertise in modifiable risk factors for dementia including depression, cardiovascularcognitive training and sleep and circadian disturbance and has published over 275 articles. She is interested in the neuroimaging correlates of sleep disturbance in older people, screening for sleep disturbance in ‘at risk’, older adults, delineating how changes in sleep contribute to poor learning and memory in MCI, and in interventions targeting sleep disturbance. She leads a multidisciplinary team of over 20 ECRs, clinician scientists and students.
Programs Chair: Erik Musiek
I am an Associate Professor of Neurology at Washington University School of Medicine in St. Louis, MO, USA. My research focuses on how the circadian clock in the brain of mice regulates glial activation, oxidative stress, synaptic degeneration, and pathogenic protein aggregation in models of Alzheimer’s Disease (AD). My lab and collaborators also study how circadian dysfunction contributes to AD pathogenesis in humans, with an aim to develop new biomarkers of AD based on circadian transcriptomics.I am also a practicing neurologist with a specialization in dementia and conduct human AD research at the Knight AD Research Center at Washington University. I am a member of the Sleep Research Society Scientific Content Committee, site PI for the Longitudinal Early-onset Alzheimer’s Disease Study (LEADS), and a standing member of the NIH Neuroimmunology, Neuroendocrinology, Rhythms, and Sleep (NNRS) study section
Musiek ES, Lim MM, Yang G, Bauer AQ, Qi, L, Lee, Y, Roh, JH, Ortiz-Gonzalez X, Dearborn JT, Culver JP, Herzog ED, Hogenesch JB, Wozniak DF, Dikranian K, Giasson BI, Weaver DR, Holtzman DM, FitzGerald GA (2013) Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J Clin Invest, 123; 5389-400.
Musiek ES and Holtzman DM (2016) Mechanisms linking circadian clocks, sleep, and neurodegeneration. Science, 354: 1004-8.
Musiek ES, Bhimasani M, Zangrilli MA, Morris JC, Holtzman DM, Ju YS (2018) Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease. JAMA Neurol, 75:582-590
Kress GJ, Liao F, Dimitry J, Cedeno MR, FitzGerald GA, Holtzman DM, Musiek ES (2018) Regulation of amyloid-β dynamics and pathology by the circadian clock. J Exp Med, 215:1059-1068.
Lananna BV, Nadarajah CJ, Izumo M, Cedeño MR, Xiong DD, Dimitry J, Tso CF, McKee CA, Griffin P, Sheehan PW, Haspel JA, Barres BA, Liddelow SA, Takahashi JS, Karatsoreos IN, Musiek ES (2018) Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1. Cell Rep, 25:1-9.e5
Communications Chair: Julie Carrier
Biography is coming soon.