PIA Executive Committee:

Sleep and Circadian Rhythms

Chair: Géraldine Rauchs

I work at the French National Institute of health and Medical Research (Inserm). My work aims at better understanding the associations between sleep quality, assessed using different tools, and structural, functional and molecular brain alterations in aging and in the early stages of Azheimer’s disease. I am also interested in the role of sleep in memory consolidation. I use various methodologies such as polysomnography, spectral analyses, neuroimaging (structural and functional MRI, PET), actigraphy and cognitive testing. I am also member of the scientific committee of the French Society for Sleep Research and Medicine (SFRSMS).

Relevant publications:

 * André C, Rehel S, …, Chételat G, Rauchs G; for the Medit-Ageing Research Group. Association of sleep-disordered breathing with Alzheimer's disease biomarkers in community-dwelling older adults: A secondary analysis of a randomized clinical trial. JAMA Neurol., 2020 Mar 23. doi: 10.1001/jamaneurol.2020.0311.

 * André C, Tomadesso C, de Flores R, Branger P, Rehel S, Mézenge F,... Rauchs G. Brain and cognitive correlates of sleep fragmentation in elderly subjects with and without cognitive deficits. Alzheimers Dement (Amst)., 2019, 11:142-150.  

 * Branger P, Arenaza-Urquijo EM, Tomadesso C, Mézenge F, André C, de Flores R, ... Rauchs G. Relationships between sleep quality and brain volume, metabolism and amyloid deposition in late adulthood. Neurobiol. Aging, 2016, 41: 107-114.   

Vice Chair: Sharon Naismith
Prof Naismith is a Clinical Neuropsychologist, National Health and Medical Research Council (NHMRC) Dementia Leadership Fellow and the Leonard P Ullman Chair in Psychology at the University of Sydney, Australia. 
She leads as Chief Investigator an NHMRC Centre of Research Excellence to “Optimise Sleep in Brain Ageing and Neurodegeneration (CogSleep)”. She is also a Chief Investigator on the NHMRC Australian Dementia Network (ADNeT), and leads the nationwide memory clinics initiative. She is Chair of the Sydney Dementia Network and in 2019, formed the Global Consortia for Sleep, Ageing and Neurodegeneration.  She has expertise in modifiable risk factors for dementia including depression, cardiovascularcognitive training and sleep and circadian disturbance and has published over 275 articles. She is interested in the neuroimaging correlates of sleep disturbance in older people, screening for sleep disturbance in ‘at risk’, older adults, delineating how changes in sleep contribute to poor learning and memory in MCI, and in interventions targeting sleep disturbance. She leads a multidisciplinary team of over 20 ECRs, clinician scientists and students.  

Programs Chair: Erik Musiek
I am an Associate Professor of Neurology at Washington University School of Medicine in St. Louis, MO, USA. My research focuses on how the circadian clock in the brain of mice regulates glial activation, oxidative stress, synaptic degeneration, and pathogenic protein aggregation in models of Alzheimer’s Disease (AD). My lab and collaborators also study how circadian dysfunction contributes to AD pathogenesis in humans, with an aim to  develop new biomarkers of AD based on circadian transcriptomics.I am also a practicing neurologist with a specialization in dementia and conduct human AD research at the Knight AD Research Center at Washington University. I am a member of the Sleep Research Society Scientific Content Committee, site PI for the Longitudinal Early-onset Alzheimer’s Disease Study (LEADS), and a standing member of the NIH Neuroimmunology, Neuroendocrinology, Rhythms, and Sleep (NNRS) study section

Select Publications:
 * Musiek ES, Lim MM, Yang G, Bauer AQ, Qi, L, Lee, Y, etal. (2013) Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J Clin Invest, 123; 5389-400.
 * Musiek ES and Holtzman DM (2016) Mechanisms linking circadian clocks, sleep, and neurodegeneration. Science, 354: 1004-8.
 * Musiek ES, Bhimasani M, Zangrilli MA, Morris JC, Holtzman DM, Ju YS (2018) Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease. JAMA Neurol, 75:582-590
 * Kress GJ, Liao F, Dimitry J, Cedeno MR, FitzGerald GA, Holtzman DM, Musiek ES (2018) Regulation of amyloid-β dynamics and pathology by the circadian clock. J Exp Med, 215:1059-1068.
 * Lananna BV, Nadarajah CJ, Izumo M, Cedeño MR, Xiong DD, ... Musiek ES (2018) Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1. Cell Rep, 25:1-9.e5

 Communications Chair: Kristine Wilckens
Dr. Wilckens is an Assistant Professor of Psychiatry at the University of Pittsburgh School of Medicine. She has expertise in sleep as a promotor of brain health and cognition. Her work focuses on the mechanistic links of sleep with cognitive aging, Alzheimer’s disease pathophysiology, and neurodegeneration. She currently uses behavioral and technically advanced sleep interventions to examine how improvements in sleep architecture affect cognition and Alzheimer’s disease pathophysiology. She received graduate training in Cognitive Psychology and Cognitive Neuroscience from New York University and the University of Pittsburgh. She receive postdoctoral training in Sleep Medicine and Geriatric Mental Health from the University of Pittsburgh School of Medicine. 
Selected publications:
 * Wilckens KA, Tudorascu DL, Snitz BE, Price JC, Aizenstein HJ, Lopez OL, etal. Sleep efficiency moderates the relationship between beta amyloid and memory retention in older adults. Neurobiology of Aging. 2018. 71, 142-148. 
 * Wilckens KA, Ferrarelli F, Walker MP, Buysse DJ. Slow-wave sleep enhancement to improve cognition. Trends in Neurosciences. 2018; 41(7), 470-482.Wilckens, K.A., Erickson, K.I., Wheeler, M.E. Physical activity and executive function: a mediating role of efficient sleep. Behavioral Sleep Medicine. 2016; 1-18.
 * Wilckens KA, Nebes R, Hall M, Monk T, Buysse DJ. Changes in Cognitive Performance are Associated with Changes in Sleep in Older Adults with Insomnia. Behavioral Sleep Medicine. 2016; 1-16.

 Postdoctoral Member: Claire André
Claire André graduated with a Master’s degree in Neuroscience from the University of Caen Normandy, and completed a PhD in Psychology under the supervision of Drs. Géraldine Rauchs and Gaël Chételat (Caen, France). Her work investigated the associations between age-related sleep changes and brain integrity, using multimodal neuroimaging (structural MRI, FDG and Amyloid-PET). She joined the team of Dr. Nadia Gosselin (Center for Advanced Research in Sleep Medicine, Montréal, Canada) in September 2020 to study the relationships between REM sleep alterations, sleep apnea, and the neurodegeneration of the cholinergic system in older adults and patients with Mild Cognitive Impairment. 

 Student Member: Inga M. Antonsdottir 
Inga Antonsdottir is working towards obtaining her PhD and DNP degrees at the Johns Hopkins School of Nursing. Her dissertation and research focus are in studying sleep and circadian rest activity rhythms in persons with Alzheimer's disease and their caregivers. Her clinical focus is in the Adult and Geriatric Primary Care population, with special interest in persons with memory impairment. 

 Student Member: Caitlin Carroll 
I am a PhD Candidate in Neuroscience in the lab of Shannon Macauley, PhD at Wake Forest University in Winston-Salem, NC, USA. My research focuses on the interactions between peripheral and brain metabolic perturbations, sleep disruptions, and pathology accumulation in models of Alzheimer’s disease. Ultimately, I am interested in understanding how lifestyle modifications, like improvements in sleep quality, can alter the progression of disease development. My PhD work is funded through a pre-doctoral F31 fellowship from the National Institute on Aging (NIH). Prior to joining the PhD program at Wake Forest, Caitlin received her undergraduate degree from Middlebury College in 2017 where I studied the physiological need for sleep under the mentorship of Michael Dash, PhD.